Techniques for Molecular Imaging Probe Design

Luminescent Probe Based Techniques for Hypoxia Imaging

Hypoxia refers to an inadequate oxygen supply or low oxygen concentration and is the major cause of various diseases as oxygen plays a crucial role in many pathological and physiological processes in biological systems [1]. Hypoxic conditions i.e. areas with pO2 values ≤2.5 mmHg are known to be associated with solid tumors, stroke, cardiac ischemia, inflammatory diseases [2-5], vascular disease...

In vitro Study of SPIONs-C595 as Molecular Imaging Probe for Specific Breast Cancer (MCF-7) Cells Detection

Background: Magnetic resonance imaging (MRI) plays an essential role in molecular imaging by delivering the contrast agent into targeted cancer cells. The aim of this study was to evaluate the C595 monoclonal antibody-conjugated superparamagnetic iron oxide nanoparticles (SPIONs-C595) for the detection of breast cancer cell (MCF-7). Methods: The conjugation of monoclonal antibody and nanopartic...

Acoustical - Molecular Techniques for Magnetic Resonance Imaging

Molecular imaging probe development: a chemistry perspective.

Molecular imaging is an attractive modality that has been widely employed in many aspects of biomedical research; especially those aimed at the early detection of diseases such as cancer, inflammation and neurodegenerative disorders. The field emerged in response to a new research paradigm in healthcare that seeks to integrate detection capabilities for the prediction and prevention of diseases...

Cardiovascular Molecular Imaging Imaging Techniques and Quantification

Cardiovascular diseases (CVD) remain the leading cause of morbidity and mortality in the western world and developing countries. Diseases affecting the cardiovascular system are expected to be the main cause of death globally within the next 20 years. This is due to the rising prevalence of CVD in the eastern parts of Europe, developing countries and an increasing incidence of obesity and diabe...